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Research Article

MSH3-Deficiency Initiates EMAST without Oncogenic Transformation of Human Colon Epithelial Cells

  • Christoph Campregher,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Gerald Schmid,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Franziska Ferk,

    Affiliation: Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria

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  • Siegfried Knasmüller,

    Affiliation: Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria

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  • Vineeta Khare,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Benedikt Kortüm,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Kyle Dammann,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Michaela Lang,

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Theresa Scharl,

    Affiliations: ACIB GmbH, c/o Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria, Department of Statistics and Probability Theory, University of Technology, Vienna, Austria

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  • Andreas Spittler,

    Affiliation: Department of Surgery, Research Laboratories & Core Facility Flow Cytometry, Medical University of Vienna, Vienna, Austria

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  • Andres I. Roig,

    Affiliation: Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Jerry W. Shay,

    Affiliation: Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Christopher Gerner,

    Affiliation: Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

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  • Christoph Gasche mail

    christoph.gasche@meduniwien.ac.at

    Affiliation: Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria

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  • Published: November 27, 2012
  • DOI: 10.1371/journal.pone.0050541

About the Authors

Christoph Campregher, Gerald Schmid, Vineeta Khare, Benedikt Kortüm, Kyle Dammann, Michaela Lang, Christoph Gasche
Christian Doppler Laboratory for Molecular Cancer Chemoprevention, Division of Gastroenterology and Hepatology, Department of Medicine 3, Medical University of Vienna, Vienna, Austria
Franziska Ferk, Siegfried Knasmüller
Institute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria
Theresa Scharl
ACIB GmbH, c/o Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria
Theresa Scharl
Department of Statistics and Probability Theory, University of Technology, Vienna, Austria
Andreas Spittler
Department of Surgery, Research Laboratories & Core Facility Flow Cytometry, Medical University of Vienna, Vienna, Austria
Andres I. Roig, Jerry W. Shay
Department of Cell Biology, Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Christopher Gerner
Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria

Corresponding Author

Email: christoph.gasche@meduniwien.ac.at

Competing Interests

CG has ongoing research collaborations with AOP Orphan Pharmaceuticals, Biogena Naturstoffe GmbH, and Shire Pharmaceuticals, and received research support, lecturing or consulting honoraria from AstraZeneca Austria, Ferring Int., Dr. Falk Pharma, Fresenius Medical Care, Minos Medical Inc., Pharmacosmos A/S, Renapharma Sweden, Shire Inc., Vifor Int., and Vifor Österreich. This does not alter the authors' adherence to the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CC C. Gasche GS C. Gerner VK. Performed the experiments: CC C. Gerner GS BK FF AS KD ML. Analyzed the data: CC TS FF SK C. Gerner. Contributed reagents/materials/analysis tools: AIR JWS. Wrote the paper: CC.