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Research Article

WIKI4, a Novel Inhibitor of Tankyrase and Wnt/ß-Catenin Signaling

  • Richard G. James equal contributor,

    equal contributor Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    Current address: Center for Immunity and Immunotherapies, Seattle Children’s Research Institute, Seattle, Washington, United States of America

    X
  • Kathryn C. Davidson equal contributor,

    equal contributor Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Katherine A. Bosch equal contributor,

    equal contributor Contributed equally to this work with: Richard G. James, Kathryn C. Davidson, Katherine A. Bosch

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Travis L. Biechele,

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Nicholas C. Robin,

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Russell J. Taylor,

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Michael B. Major,

    Affiliation: Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, North Carolina, United States of America

    X
  • Nathan D. Camp,

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Kerry Fowler,

    Affiliation: KWF Consulting, Seattle, Washington, United States of America

    X
  • Timothy J. Martins,

    Affiliations: Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Quellos High Throughput Screening Core, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Randall T. Moon mail

    rtmoon@uw.edu

    Affiliations: Department of Pharmacology, Seattle, Washington, United States of America, Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America, University of Washington School of Medicine, Seattle, Washington, United States of America

    X
  • Published: December 05, 2012
  • DOI: 10.1371/journal.pone.0050457

About the Authors

Richard G. James, Kathryn C. Davidson, Katherine A. Bosch, Travis L. Biechele, Nicholas C. Robin, Russell J. Taylor, Nathan D. Camp, Randall T. Moon
Department of Pharmacology, Seattle, Washington, United States of America
Richard G. James, Kathryn C. Davidson, Katherine A. Bosch, Travis L. Biechele, Nicholas C. Robin, Russell J. Taylor, Nathan D. Camp, Timothy J. Martins, Randall T. Moon
Institute for Stem Cell and Regenerative Medicine, Seattle, Washington, United States of America
Kathryn C. Davidson, Katherine A. Bosch, Travis L. Biechele, Nicholas C. Robin, Nathan D. Camp, Randall T. Moon
Howard Hughes Medical Institute, Seattle, Washington, United States of America
Timothy J. Martins
Quellos High Throughput Screening Core, Seattle, Washington, United States of America
Richard G. James, Kathryn C. Davidson, Katherine A. Bosch, Travis L. Biechele, Nicholas C. Robin, Russell J. Taylor, Nathan D. Camp, Timothy J. Martins, Randall T. Moon
University of Washington School of Medicine, Seattle, Washington, United States of America
Michael B. Major
Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, North Carolina, United States of America
Kerry Fowler
KWF Consulting, Seattle, Washington, United States of America

Corresponding Author

Email: rtmoon@uw.edu

Competing Interests

The authors have read the journal’s policy and have the following conflicts: RTM is a co-founder of, and consultant with, FATE THERAPEUTICS, San Diego.

Author Contributions

Conceived and designed the experiments: RGJ KCD TLB NCR MBM NDC KWF RTM. Performed the experiments: RGJ KCD KAB NCR RJT TJM. Analyzed the data: RGJ KCD NCR KWF TJM. Contributed reagents/materials/analysis tools: TJM. Wrote the paper: RGJ KCD KWF RTM.