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Research Article

Generation of an Rx-tTA: TetOp-Cre Knock-In Mouse Line for Doxycycline Regulated Cre Activity in the Rx Expression Domain

  • Timothy F. Plageman Jr.,

    Affiliations: Visual Systems Group, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Division of Pediatric Ophthalmology, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America

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  • Richard A. Lang mail

    Richard.Lang@cchmc.org

    Affiliations: Visual Systems Group, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Division of Pediatric Ophthalmology, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, United States of America

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  • Published: November 27, 2012
  • DOI: 10.1371/journal.pone.0050426

About the Authors

Timothy F. Plageman Jr., Richard A. Lang
Visual Systems Group, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Timothy F. Plageman Jr., Richard A. Lang
Division of Pediatric Ophthalmology, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Richard A. Lang
Division of Developmental Biology, Children's Hospital Research Foundation, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Richard A. Lang
Department of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, United States of America

Corresponding Author

Email: Richard.Lang@cchmc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TP RL. Performed the experiments: TP. Analyzed the data: TP RL. Contributed reagents/materials/analysis tools: TP RL. Wrote the paper: TP RL.