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Research Article

17ß-Estradiol Antagonizes the Down-Regulation of ERα/NOS-3 Signaling in Vascular Endothelial Dysfunction of Female Diabetic Rats

  • Yi Han equal contributor,

    equal contributor Contributed equally to this work with: Yi Han, Xiaozhen Li, Suming Zhou

    Affiliation: Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Xiaozhen Li equal contributor,

    equal contributor Contributed equally to this work with: Yi Han, Xiaozhen Li, Suming Zhou

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Suming Zhou equal contributor,

    equal contributor Contributed equally to this work with: Yi Han, Xiaozhen Li, Suming Zhou

    Affiliation: Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Guoliang Meng,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Yujiao Xiao,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Wen Zhang,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Zhuoying Wang,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Liping Xie,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Zhen Liu,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Hui Lu,

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Yong Ji mail

    yongji@njmu.edu.cn

    Affiliation: State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

    X
  • Published: November 29, 2012
  • DOI: 10.1371/journal.pone.0050402

About the Authors

Yi Han, Suming Zhou
Department of Geriatrics, the First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China
Xiaozhen Li, Guoliang Meng, Yujiao Xiao, Wen Zhang, Zhuoying Wang, Liping Xie, Zhen Liu, Hui Lu, Yong Ji
State Key Laboratory of Reproductive Medicine, Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, People’s Republic of China

Corresponding Author

Email: yongji@njmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YJ. Performed the experiments: YH XL SZ GM YX WZ ZW LX ZL HL. Analyzed the data: YH XL SZ GM. Contributed reagents/materials/analysis tools: YH XL SZ GM YJ. Wrote the paper: YH GM YJ.