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Research Article

Coating with a Modular Bone Morphogenetic Peptide Promotes Healing of a Bone-Implant Gap in an Ovine Model

  • Yan Lu mail,

    luy@svm.vetmed.wisc.edu (YL); wlmurphy@wisc.edu (WLM)

    Affiliations: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Jae Sung Lee,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Brett Nemke,

    Affiliation: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America

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  • Ben K. Graf,

    Affiliation: Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Kevin Royalty,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Richard Illgen III,

    Affiliation: Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Ray Vanderby Jr,

    Affiliation: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America

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  • Mark D. Markel,

    Affiliations: Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • William L. Murphy mail

    luy@svm.vetmed.wisc.edu (YL); wlmurphy@wisc.edu (WLM)

    Affiliations: Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America, Pharmacology, University of Wisconsin, Madison, Wisconson, United States of America, Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

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  • Published: November 21, 2012
  • DOI: 10.1371/journal.pone.0050378

About the Authors

Yan Lu, Brett Nemke, Mark D. Markel
Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconson, United States of America
Jae Sung Lee, Kevin Royalty, Ray Vanderby Jr, William L. Murphy
Departments of Biomedical Engineering, University of Wisconsin, Madison, Wisconson, United States of America
William L. Murphy
Pharmacology, University of Wisconsin, Madison, Wisconson, United States of America
Yan Lu, Ben K. Graf, Richard Illgen III, Mark D. Markel, William L. Murphy
Orthopedics and Rehabilitation, University of Wisconsin, Madison, Wisconson, United States of America

Corresponding Authors

Competing Interests

Smith&Nephew, Inc., provided titanium implants for this study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: YL JSL BKG RI RV MDM WLM. Performed the experiments: YL JSL BN. Analyzed the data: YL JSL KR RV MDM WLM. Contributed reagents/materials/analysis tools: JSL KR MDM WLM. Wrote the paper: YL. Proofread the manuscript: MDM, WLM.