About the Authors

Christiane Reitz

Affiliations The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Giuseppe Tosto

Affiliation The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Richard Mayeux

rpm2@columbia.edu

Affiliations The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America, Department of Medicine, Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Jose A. Luchsinger

Membership of the NIA-LOAD/NCRAD Family Study Group and the Alzheimer's Disease Neuroimaging Initiative (ADNI) is provided in the Acknowledgments.

Affiliation Department of Medicine, Pathology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Competing Interests

ADNI is partly funded through generous contributions from the following: Abbott; Amorfix Life Sciences Ltd.; AstraZeneca; Bayer HealthCare; BioClinica, Inc.; Biogen Idec Inc.; Bristol-Myers Squibb Company; Eisai Inc.; Elan Pharmaceuticals Inc.; Eli Lilly and Company; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.; GE Healthcare; Innogenetics, N.V.; Janssen Alzheimer Immunotherapy Research & Development, LLC.; Johnson & Johnson Pharmaceutical Research & Development LLC.; Medpace, Inc.; Merck & Co., Inc.; Meso Scale Diagnostics, LLC.; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Servier; Synarc Inc.; and Takeda Pharmaceutical Company. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CR GT RM JL. Performed the experiments: CR GT. Analyzed the data: CR GT. Contributed reagents/materials/analysis tools: CR GT RM JL. Wrote the paper: CR GT RM JL.