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Research Article

Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts

  • Sebastian Seitz equal contributor,

    equal contributor Contributed equally to this work with: Sebastian Seitz, Johannes Keller, Arndt F. Schilling

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Johannes Keller equal contributor,

    equal contributor Contributed equally to this work with: Sebastian Seitz, Johannes Keller, Arndt F. Schilling

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Arndt F. Schilling equal contributor,

    equal contributor Contributed equally to this work with: Sebastian Seitz, Johannes Keller, Arndt F. Schilling

    Affiliations: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, Department of Plastic and Hand Surgery, Technische Universität München, Munich, Germany

    X
  • Anke Jeschke,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Robert P. Marshall,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Brenda D. Stride,

    Affiliation: Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany

    X
  • Tim Wintermantel,

    Affiliation: Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany

    X
  • Frank T. Beil,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Michael Amling,

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Günther Schütz,

    Affiliation: Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany

    X
  • Jan Tuckermann mail,

    jan@fli-leibniz.de (JT); schinke@uke.de (TS)

    Affiliation: Leibniz Institute for Age Research-Fritz Lipmann Institute, Jena, Germany

    X
  • Thorsten Schinke mail

    jan@fli-leibniz.de (JT); schinke@uke.de (TS)

    Affiliation: Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    X
  • Published: November 27, 2012
  • DOI: 10.1371/journal.pone.0050301

About the Authors

Sebastian Seitz, Johannes Keller, Arndt F. Schilling, Anke Jeschke, Robert P. Marshall, Frank T. Beil, Michael Amling, Thorsten Schinke
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Arndt F. Schilling
Department of Plastic and Hand Surgery, Technische Universität München, Munich, Germany
Brenda D. Stride, Tim Wintermantel, Günther Schütz
Division Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
Jan Tuckermann
Leibniz Institute for Age Research-Fritz Lipmann Institute, Jena, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA GS JT TS. Performed the experiments: SS JK AFS AJ RPM BDS FTB TW. Analyzed the data: JK JT TS. Wrote the paper: JK JT TS.