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Research Article

ERK1/2 Signaling Plays an Important Role in Topoisomerase II Poison-Induced G2/M Checkpoint Activation

  • Ryan H. Kolb,

    Affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Patrick M. Greer,

    Affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Phu T. Cao,

    Affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Kenneth H. Cowan,

    Affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Ying Yan mail

    yyan@unmc.edu

    Affiliation: Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050281

About the Authors

Ryan H. Kolb, Patrick M. Greer, Phu T. Cao, Kenneth H. Cowan, Ying Yan
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Corresponding Author

Email: yyan@unmc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RHK PMG PTC KHC YY. Performed the experiments: RHK YY. Analyzed the data: RHK KHC YY. Contributed reagents/materials/analysis tools: PMG PTC KHC YY. Wrote the paper: RHK YY.