Advertisement
Research Article

Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content

  • Hanna Appelqvist mail,

    hanna.appelqvist@liu.se

    Affiliation: Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

    X
  • Linnea Sandin,

    Affiliation: Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

    X
  • Karin Björnström,

    Affiliations: Anaesthesiology, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden, Department of Anaesthesiology UHL, County Council of Östergötland, Linköping, Sweden

    X
  • Paul Saftig,

    Affiliation: Biochemical Institute, Christian-Albrechts-University Kiel, Kiel, Germany

    X
  • Brett Garner,

    Affiliations: Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia, School of Biological Sciences, University of Wollongong, Wollongong, Australia

    X
  • Karin Öllinger,

    Affiliations: Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden, Department of Clinical Pathology and Clinical Genetics, County Council of Östergötland, Linköping, Sweden

    X
  • Katarina Kågedal

    Affiliation: Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

    X
  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050262

About the Authors

Hanna Appelqvist, Linnea Sandin, Karin Öllinger, Katarina Kågedal
Experimental Pathology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
Karin Björnström
Anaesthesiology, Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden
Karin Björnström
Department of Anaesthesiology UHL, County Council of Östergötland, Linköping, Sweden
Paul Saftig
Biochemical Institute, Christian-Albrechts-University Kiel, Kiel, Germany
Brett Garner
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, Australia
Brett Garner
School of Biological Sciences, University of Wollongong, Wollongong, Australia
Karin Öllinger
Department of Clinical Pathology and Clinical Genetics, County Council of Östergötland, Linköping, Sweden

Corresponding Author

Email: hanna.appelqvist@liu.se

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA LS KB PS BG KÖ KK. Performed the experiments: HA LS. Analyzed the data: HA LS BG KÖ KK. Wrote the paper: HA LS KB PS BG KÖ KK.