About the Authors

Clara C. Elbers

Contributed equally to this work with: Clara C. Elbers, Yiran Guo

Affiliations Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Medical Genetics, Biomedical Genetics, University Medical Center, Utrecht, The Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

Yiran Guo

Contributed equally to this work with: Clara C. Elbers, Yiran Guo

Affiliations Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, BGI-Shenzhen, Shenzhen, People's Republic of China

Vinicius Tragante

Affiliations Department of Medical Genetics, Biomedical Genetics, University Medical Center, Utrecht, The Netherlands, Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

Erik P. A. van Iperen

Affiliation Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Matthew B. Lanktree

Affiliation Departments of Medicine and Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

Berta Almoguera Castillo

Affiliation Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Fang Chen

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

Lisa R. Yanek

Affiliation GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

Mary K. Wojczynski

Affiliations Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, Division of Statistical Genomics and Department of Genetics Washington University School of Medicine, St. Louis, Missouri, United States of America

Yun R. Li

Affiliation Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Bart Ferwerda

Affiliation Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America

Christie M. Ballantyne

Affiliation Baylor College of Medicine, Houston, Texas, United States of America

Sarah G. Buxbaum

Affiliations Jackson Heart Study, Jackson State University, Jackson, Mississippi, United States of America, School of Health Sciences, Department of Epidemiology and Biostatistics, Jackson State University, Jackson, Mississippi, United States of America

Yii-Der Ida Chen

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Wei-Min Chen

Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America

L. Adrienne Cupples

Affiliations Boston University, Boston, Massachusetts, United States of America, The National Heart, Lung, Blood Institute's Framingham Heart Study, Framingham, Massachusetts, United States of America

Mary Cushman

Affiliation Department of Medicine, Thrombosis and Hemostasis Program, University of Vermont, Burlington, Vermont, United States of America

Yanan Duan

Affiliation Division of Statistical Genomics and Department of Genetics Washington University School of Medicine, St. Louis, Missouri, United States of America

David Duggan

Affiliation Translational Genomics Research Institute, Phoenix, Arizona, United States of America

Michele K. Evans

Affiliation Health Disparities Unit, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

Jyotika K. Fernandes

Affiliation Division of Endocrinology, Diabetes and Medical Genetics, College of Medicine, Medical University of South Carolina, Charleston, SC United States of America

Myriam Fornage

Affiliation The University of Texas Health Science Center at Houston, Houston, Texas, United States of America

Melissa Garcia

Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

W. Timothy Garvey

Affiliation Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Nicole Glazer

Affiliation Boston University, Boston, Massachusetts, United States of America

Felicia Gomez

Affiliation Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, United States of America

Tamara B. Harris

Affiliation Laboratory for Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Indrani Halder

Affiliation Heart and Vascular Institute, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Virginia J. Howard

Affiliation Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

Margaux F. Keller

Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

M. Ilyas Kamboh

Affiliation Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Charles Kooperberg

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Stephen B. Kritchevsky

Affiliations Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America, Sticht Center on Aging, Wake Forest University, Winston-Salem, North Carolina, United States of America

Andrea LaCroix

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Kiang Liu

Affiliation Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America

Yongmei Liu

Affiliation Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina, United States of America

Kiran Musunuru

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Anne B. Newman

Affiliation Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

N. Charlotte Onland-Moret

Affiliations Department of Medical Genetics, Biomedical Genetics, University Medical Center, Utrecht, The Netherlands, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

Jose Ordovas

Affiliation JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, United States of America

Inga Peter

Affiliation Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America

Wendy Post

Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America

Susan Redline

Affiliation Brigham and Women's Hospital and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

Steven E. Reis

Affiliation School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Richa Saxena

Affiliations Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America

Pamela J. Schreiner

Affiliation School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America

Kelly A. Volcik

Affiliation Division of Epidemiology, Human Genetics and Environmental Sciences, Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, Texas, United States of America

Xingbin Wang

Affiliation Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Salim Yusuf

Affiliation Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada

Alan B. Zonderland

Affiliation Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Sonia S. Anand

Affiliation Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada

Diane M. Becker

Affiliation GeneSTAR Research Program, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

Bruce Psaty

Affiliations Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, Washington, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle, Washington, United States of America

Daniel J. Rader

Affiliation Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Alex P. Reiner

Affiliation Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

Stephen S. Rich

Affiliation Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America

Jerome I. Rotter

Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

Michèle M. Sale

Affiliations Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, United States of America, Department of Medicine, University of Virginia, Charlottesville, Virginia, United States of America

Michael Y. Tsai

Affiliation Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, United States of America

Ingrid B. Borecki

Affiliation Division of Statistical Genomics and Department of Genetics Washington University School of Medicine, St. Louis, Missouri, United States of America

Robert A. Hegele

Affiliation Robarts Research Institute, University of Western Ontario, London, Ontario, Canada

Sekar Kathiresan

Affiliations Broad Institute, Cambridge, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Michael A. Nalls

Affiliation Laboratory of Neurogenetics, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

Herman A. Taylor Jr

Affiliation Jackson State University, Tougaloo College, and the University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Hakon Hakonarson

Affiliation Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Suthesh Sivapalaratnam

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

Folkert W. Asselbergs

Affiliations Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Medical Genetics, Biomedical Genetics, University Medical Center, Utrecht, The Netherlands, Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands

Fotios Drenos

Affiliation Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom

James G. Wilson

Affiliation Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, United States of America

Brendan J. Keating

bkeating@mail.med.upenn.edu

Affiliation Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CCE FWA FD JGW BJK. Performed the experiments: VT EPAvI MBL BAC FC LRY MKW YRL BF CMB YDIC WMC LAC YD DD MF MG NG FG TBH CK SBK AL KL YL KM ABN NCOM JO IP WP RS PJS KAV SY SSA DMB BP APR SSR JIR MMS MYT IBB RAH SK MAN DJR HH SS BJK SGB HAT SER SR MC MKE JKF WTG IH VJH MFK MIK XW ABZ. Analyzed the data: CCE YG VT BJK. Contributed reagents/materials/analysis tools: FD FWA FD JGW BJK. Wrote the paper: CCE VT FD FWA FD JGW BJK.