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Research Article

Antagonistic and Cooperative Actions of Kif7 and Sufu Define Graded Intracellular Gli Activities in Hedgehog Signaling

  • Kelvin King Lo Law,

    Affiliations: Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Shigeru Makino,

    Affiliation: Mutagenesis and Genomics Team, RIKEN BioResource Center, Koyadai, Tsukuba, Ibaraki, Japan

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  • Rong Mo,

    Affiliation: Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada

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  • Xiaoyun Zhang,

    Affiliation: Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada

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  • Vijitha Puviindran,

    Affiliation: Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada

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  • Chi-chung Hui mail

    cchui@sickkids.ca

    Affiliations: Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050193

About the Authors

Kelvin King Lo Law, Rong Mo, Xiaoyun Zhang, Vijitha Puviindran, Chi-chung Hui
Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto Medical Discovery Tower, Toronto, Ontario, Canada
Kelvin King Lo Law, Chi-chung Hui
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
Shigeru Makino
Mutagenesis and Genomics Team, RIKEN BioResource Center, Koyadai, Tsukuba, Ibaraki, Japan

Corresponding Author

Email: cchui@sickkids.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KL CCH. Performed the experiments: KL SM RM XZ VP. Analyzed the data: KL SM RM XZ. Wrote the paper: KL CCH.