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Research Article

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme

  • Minkoo Ahn,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Erwin De Genst,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Gabriele S. Kaminski Schierle,

    Affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

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  • Miklos Erdelyi,

    Affiliations: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom, National Physics Laboratory, Teddington, United Kingdom

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  • Clemens F. Kaminski,

    Affiliation: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom

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  • Christopher M. Dobson,

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Janet R. Kumita mail

    jrk38@cam.ac.uk

    Affiliation: Department of Chemistry, University of Cambridge, Cambridge, United Kingdom

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050192

About the Authors

Minkoo Ahn, Erwin De Genst, Christopher M. Dobson, Janet R. Kumita
Department of Chemistry, University of Cambridge, Cambridge, United Kingdom
Gabriele S. Kaminski Schierle, Miklos Erdelyi, Clemens F. Kaminski
Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom
Miklos Erdelyi
National Physics Laboratory, Teddington, United Kingdom

Corresponding Author

Email: jrk38@cam.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA GSKS CMD JRK. Performed the experiments: MA ED GSKS ME JRK. Analyzed the data: MA ED GSKS ME CFK CMD JRK. Contributed reagents/materials/analysis tools: MA ED GSKS ME CFK CMD JRK. Wrote the paper: MA CFK CMD JRK.