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Research Article

Progesterone Acts via the Nuclear Glucocorticoid Receptor to Suppress IL-1β-Induced COX-2 Expression in Human Term Myometrial Cells

  • Kaiyu Lei,

    Affiliations: Chelsea and Westminster Hospital, London, United Kingdom, Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Li Chen,

    Affiliations: Chelsea and Westminster Hospital, London, United Kingdom, Department of Obstetrics and Gynecology, Third Military Medical University Southwest Hospital, Chongqing, P. R. China

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  • Ektoras X. Georgiou,

    Affiliation: Chelsea and Westminster Hospital, London, United Kingdom

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  • Suren R. Sooranna,

    Affiliations: Chelsea and Westminster Hospital, London, United Kingdom, Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Shirin Khanjani,

    Affiliation: Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Jan J. Brosens,

    Affiliation: Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Phillip R. Bennett,

    Affiliation: Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Mark R. Johnson mail

    mark.johnson@imperial.ac.uk

    Affiliations: Chelsea and Westminster Hospital, London, United Kingdom, Institute of Reproductive and Developmental Biology, London, United Kingdom

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  • Published: November 28, 2012
  • DOI: 10.1371/journal.pone.0050167

About the Authors

Kaiyu Lei, Li Chen, Ektoras X. Georgiou, Suren R. Sooranna, Mark R. Johnson
Chelsea and Westminster Hospital, London, United Kingdom
Kaiyu Lei, Suren R. Sooranna, Shirin Khanjani, Jan J. Brosens, Phillip R. Bennett, Mark R. Johnson
Institute of Reproductive and Developmental Biology, London, United Kingdom
Li Chen
Department of Obstetrics and Gynecology, Third Military Medical University Southwest Hospital, Chongqing, P. R. China

Corresponding Author

Email: mark.johnson@imperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MJ PB JB KL. Performed the experiments: KL LC EG SK SS. Analyzed the data: MJ KL. Wrote the paper: KL MJ JB PB.