Infectious Complications in Head and Neck Cancer Patients Treated with Cetuximab: Propensity Score and Instrumental Variable Analysis

Ching-Chih Lee; Hsu-Chueh Ho; Shih-Hsuan Hsiao; Tza-Ta Huang; Hon-Yi Lin; Szu-Chin Li; Pesus Chou; Yu-Chieh Su

doi:10.1371/journal.pone.0050163

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Peer-reviewed

Research Article

Infectious Complications in Head and Neck Cancer Patients Treated with Cetuximab: Propensity Score and Instrumental Variable Analysis

Ching-Chih Lee,

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Hsu-Chueh Ho,

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Shih-Hsuan Hsiao,

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Tza-Ta Huang,

Affiliation Department of Oral and Maxillofacial Surgery, Changhua Chritian Hospital, You-Lin Branch, You-Lin, Taiwan
⨯
Hon-Yi Lin,

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Szu-Chin Li,

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯
Pesus Chou,

Affiliation Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan
⨯
Yu-Chieh Su

* E-mail: hematcd2@hotmail.com

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan
⨯

Infectious Complications in Head and Neck Cancer Patients Treated with Cetuximab: Propensity Score and Instrumental Variable Analysis

Ching-Chih Lee,
Hsu-Chueh Ho,
Shih-Hsuan Hsiao,
Tza-Ta Huang,
Hon-Yi Lin,
Szu-Chin Li,
Pesus Chou,
Yu-Chieh Su

Published: November 28, 2012
https://doi.org/10.1371/journal.pone.0050163

About the Authors

Ching-Chih Lee

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan

Hsu-Chueh Ho

Affiliations Department of Otolaryngology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan

Shih-Hsuan Hsiao

Tza-Ta Huang

Affiliation Department of Oral and Maxillofacial Surgery, Changhua Chritian Hospital, You-Lin Branch, You-Lin, Taiwan

Hon-Yi Lin

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Department of Radiation Oncology, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan

Szu-Chin Li

Affiliations Cancer Center, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, Division of Hematology-Oncology, Department of Internal Medicine, Buddhist Dalin Tzu Chi General Hospital, Chiayi, Taiwan, School of Medicine, Tzu Chi University, Hualien, Taiwan

Pesus Chou

Affiliation Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Taipei, Taiwan

Yu-Chieh Su

* E-mail: hematcd2@hotmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CCL HCH SHH TTH PC YCS. Analyzed the data: CCL TTH PC. Wrote the paper: CCL HCH SHH TTH HYL SCL PC YCS.

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Cancer treatment
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Head and neck cancers
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Cancer risk factors
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Instrumental variable analysis
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Respiratory infections
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Radiation therapy
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Taiwan
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Urbanization
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