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Research Article

Cancer Associated Aberrant Protein O-Glycosylation Can Modify Antigen Processing and Immune Response

  • Caroline B. Madsen,

    Affiliations: Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark, Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Cecilie Petersen,

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Kirstine Lavrsen,

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Mikkel Harndahl,

    Affiliation: Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Søren Buus,

    Affiliation: Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Henrik Clausen,

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Anders E. Pedersen equal contributor mail,

    equal contributor Contributed equally to this work with: Anders E. Pedersen, Hans H. Wandall

    hhw@sund.ku.dk (HHW); andersep@sund.ku.dk (AEP)

    Affiliation: Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Hans H. Wandall equal contributor mail

    equal contributor Contributed equally to this work with: Anders E. Pedersen, Hans H. Wandall

    hhw@sund.ku.dk (HHW); andersep@sund.ku.dk (AEP)

    Affiliation: Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Published: November 26, 2012
  • DOI: 10.1371/journal.pone.0050139

About the Authors

Caroline B. Madsen, Cecilie Petersen, Kirstine Lavrsen, Henrik Clausen, Hans H. Wandall
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Caroline B. Madsen, Mikkel Harndahl, Søren Buus, Anders E. Pedersen
Department of International Health, Immunology and Microbiology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HHW AEP CBM SB HC. Performed the experiments: CBM CP KL MH HHW. Analyzed the data: CBM CP KL MH HHW. Contributed reagents/materials/analysis tools: HHW AEP HC SB. Wrote the paper: CBM HHW AEP SB HC MH.