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Research Article

Induction of Tumor Cell Death through Targeting Tubulin and Evoking Dysregulation of Cell Cycle Regulatory Proteins by Multifunctional Cinnamaldehydes

  • Amrita A. Nagle,

    Affiliation: Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore

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  • Fei-Fei Gan,

    Affiliation: Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore

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  • Gavin Jones,

    Affiliation: Department of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London, United Kingdom

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  • Choon-Leng So,

    Affiliation: Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore

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  • Geoffrey Wells,

    Affiliation: Department of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London, United Kingdom

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  • Eng-Hui Chew mail

    phaceh@nus.edu.sg

    Affiliation: Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore

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  • Published: November 21, 2012
  • DOI: 10.1371/journal.pone.0050125

About the Authors

Amrita A. Nagle, Fei-Fei Gan, Choon-Leng So, Eng-Hui Chew
Department of Pharmacy, National University of Singapore, Singapore, Republic of Singapore
Gavin Jones, Geoffrey Wells
Department of Pharmaceutical and Biological Chemistry, University College London School of Pharmacy, London, United Kingdom

Corresponding Author

Email: phaceh@nus.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AAN EHC. Performed the experiments: AAN FFG CLS GJ. Analyzed the data: AAN EHC. Contributed reagents/materials/analysis tools: GW EHC. Wrote the paper: AAN GW EHC.