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Research Article

Hyaluronan (HA) Interacting Proteins RHAMM and Hyaluronidase Impact Prostate Cancer Cell Behavior and Invadopodia Formation in 3D HA-Based Hydrogels

  • Lisa A. Gurski,

    Affiliations: Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Xian Xu equal contributor,

    equal contributor Contributed equally to this work with: Xian Xu, Lyana N. Labrada

    Affiliations: Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Lyana N. Labrada equal contributor,

    equal contributor Contributed equally to this work with: Xian Xu, Lyana N. Labrada

    Affiliations: Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Ngoc T. Nguyen,

    Affiliations: Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Longxi Xiao,

    Affiliations: Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Kenneth L. van Golen,

    Affiliations: Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Xinqiao Jia,

    Affiliations: Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, United States of America, The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America

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  • Mary C. Farach-Carson mail

    farachca@rice.edu

    Affiliations: Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America, Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America, Department of Bioengineering, Rice University, Houston, Texas, United States of America

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050075

About the Authors

Lisa A. Gurski, Lyana N. Labrada, Ngoc T. Nguyen, Kenneth L. van Golen, Mary C. Farach-Carson
Department of Biological Sciences, University of Delaware, Newark, Delaware, United States of America
Xian Xu, Longxi Xiao, Xinqiao Jia
Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, United States of America
Lisa A. Gurski, Xian Xu, Lyana N. Labrada, Ngoc T. Nguyen, Longxi Xiao, Kenneth L. van Golen, Xinqiao Jia
The Center for Translational Cancer Research, University of Delaware, Newark, Delaware, United States of America
Mary C. Farach-Carson
Department of Biochemistry and Cell Biology, Rice University, Houston, Texas, United States of America
Mary C. Farach-Carson
Department of Bioengineering, Rice University, Houston, Texas, United States of America

Corresponding Author

Email: farachca@rice.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LAG XX LNL NTN LX XJ KLvG MCFC. Performed the experiments: LAG XX LNL NTN LX. Analyzed the data: LAG XX LNL NTN LX. Contributed reagents/materials/analysis tools: LAG XX LNL NTN LX KLvG XJ MCFC. Wrote the paper: LAG XX LNL NTN LX KLvG XJ MCFC.