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Research Article

Helicobacter pylori Colonization Ameliorates Glucose Homeostasis in Mice through a PPAR γ-Dependent Mechanism

  • Josep Bassaganya-Riera mail,

    jbassaga@vt.edu

    Affiliations: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America, Department of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Maria Gloria Dominguez-Bello,

    Affiliation: Department of Biology, University of Puerto Rico, Río Piedras. San Juan, Puerto Rico, United States of America

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  • Barbara Kronsteiner,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Adria Carbo,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Pinyi Lu,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Monica Viladomiu,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Mireia Pedragosa,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Xiaoying Zhang,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Bruno W. Sobral,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

    Current address: Nestlé Institute of Health Sciences, Campus of the Swiss Federal Institute of Technology, Lausanne, Switzerland

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  • Shrinivasrao P. Mane,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Saroj K. Mohapatra,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • William T. Horne,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Amir J. Guri,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Michael Groeschl,

    Affiliation: Erlangen University, Erlangen, Germany

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  • Gabriela Lopez-Velasco,

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Raquel Hontecillas

    Affiliation: Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0050069

About the Authors

Josep Bassaganya-Riera, Barbara Kronsteiner, Adria Carbo, Pinyi Lu, Monica Viladomiu, Mireia Pedragosa, Xiaoying Zhang, Bruno W. Sobral, Shrinivasrao P. Mane, Saroj K. Mohapatra, William T. Horne, Amir J. Guri, Gabriela Lopez-Velasco, Raquel Hontecillas
Nutritional Immunology and Molecular Medicine Laboratory, Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, United States of America
Maria Gloria Dominguez-Bello
Department of Biology, University of Puerto Rico, Río Piedras. San Juan, Puerto Rico, United States of America
Michael Groeschl
Erlangen University, Erlangen, Germany
Josep Bassaganya-Riera
Department of Biomedical Sciences and Pathobiology, VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, United States of America

Corresponding Author

Email: jbassaga@vt.edu

Competing Interests

Corresponding author Josep Bassaganya-Riera is a PLOS ONE editorial board member. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JBR RH MGDB. Performed the experiments: JBR RH XZ WTH AJG GLV BK AC PL MV MP. Analyzed the data: SKM SPM WTH AC. Contributed reagents/materials/analysis tools: JBR RH MGDB MG. Wrote the paper: JBR RH MGDB BWS.