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Research Article

Phosphorylation of ΔNp63α via a Novel TGFβ/ALK5 Signaling Mechanism Mediates the Anti-Clonogenic Effects of TGFβ

  • Pratima Cherukuri,

    Affiliation: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • Andrew J. DeCastro,

    Affiliations: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • Amanda L. Balboni,

    Affiliations: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • Sondra L. Downey,

    Affiliations: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • Jennifer Y. Liu,

    Affiliation: Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

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  • Justine A. Hutchinson,

    Affiliations: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • James DiRenzo mail

    james.direnzo@dartmouth.edu

    Affiliations: Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America, Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0050066

About the Authors

Pratima Cherukuri, Andrew J. DeCastro, Amanda L. Balboni, Sondra L. Downey, Justine A. Hutchinson, James DiRenzo
Department of Pharmacology and Toxicology, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
Andrew J. DeCastro, Amanda L. Balboni, Sondra L. Downey, Justine A. Hutchinson, James DiRenzo
Program in Experimental Molecular Medicine, The Audrey and Theodor Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America
Jennifer Y. Liu
Department of Biological Sciences, Dartmouth College, Hanover, New Hampshire, United States of America

Corresponding Author

Email: james.direnzo@dartmouth.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDR PC. Performed the experiments: PC SLD JYL AJD. Analyzed the data: ALB JAH. Wrote the paper: JDR PC.