Advertisement
Research Article

Low Prevalence of Pneumocystis pneumonia (PCP) but High Prevalence of Pneumocystis dihydropteroate synthase (dhps) Gene Mutations in HIV-Infected Persons in Uganda

  • Steve M. Taylor mail,

    taylo115@email.unc.edu

    Affiliations: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America, Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Steven R. Meshnick,

    Affiliation: Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • William Worodria,

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Department of Medicine, Makerere College of Health Sciences, Mulago Hospital, Kampala, Uganda

    X
  • Alfred Andama,

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Department of Medicine, Makerere College of Health Sciences, Mulago Hospital, Kampala, Uganda

    X
  • Adithya Cattamanchi,

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

    X
  • J. Lucian Davis,

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

    X
  • Samuel D. Yoo,

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Health Tutors’ College Mulago, Kampala, Uganda

    X
  • Patrick Byanyima,

    Affiliation: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda

    X
  • Sylvia Kaswabuli,

    Affiliation: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda

    X
  • Carol D. Goodman,

    Affiliation: Department of Laboratory Medicine, San Francisco General Hospital, San Francisco, California, United States of America

    X
  • Laurence Huang, On behalf of the International HIV-associated Opportunistic Pneumonias (IHOP) Study

    Affiliations: Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America, HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

    Membership of the International HIV-associated Opportunistic Pneumonias (IHOP) Study is provided in the Acknowledgments.

    X
  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0049991

About the Authors

Steve M. Taylor, Steven R. Meshnick
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
Steve M. Taylor
Division of Infectious Diseases and International Health, Duke University Medical Center, Durham, North Carolina, United States of America
William Worodria, Alfred Andama, Adithya Cattamanchi, J. Lucian Davis, Samuel D. Yoo, Patrick Byanyima, Sylvia Kaswabuli, Laurence Huang
Makerere University-University of California, San Francisco Research Collaboration, Kampala, Uganda
William Worodria, Alfred Andama
Department of Medicine, Makerere College of Health Sciences, Mulago Hospital, Kampala, Uganda
Adithya Cattamanchi, J. Lucian Davis, Laurence Huang
Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
Samuel D. Yoo
Health Tutors’ College Mulago, Kampala, Uganda
Carol D. Goodman
Department of Laboratory Medicine, San Francisco General Hospital, San Francisco, California, United States of America
Laurence Huang
HIV/AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: taylo115@email.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SMT SRM WW SDY LH. Performed the experiments: SMT WW SDY PB SK CDG. Analyzed the data: SMT WW AA JLD AC SDY LH. Contributed reagents/materials/analysis tools: WW AA PB SK CDG. Wrote the paper: SMT SRM LH.