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Research Article

What Does It Take to Synergistically Combine Sub-Potent Natural Products into Drug-Level Potent Combinations?

  • Chu Qin,

    Affiliations: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China, Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore, NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore

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  • Kai Leng Tan,

    Affiliation: Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore

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  • Cun Long Zhang,

    Affiliations: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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  • Chun Yan Tan,

    Affiliations: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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  • Yu Zong Chen mail,

    phacyz@nus.edu.sg (YZC); Jiangyy@sz.tsinghua.edu.cn (YYJ)

    Affiliations: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China, Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore

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  • Yu Yang Jiang mail

    phacyz@nus.edu.sg (YZC); Jiangyy@sz.tsinghua.edu.cn (YYJ)

    Affiliations: Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China, The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China

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  • Published: November 28, 2012
  • DOI: 10.1371/journal.pone.0049969

About the Authors

Chu Qin, Cun Long Zhang, Chun Yan Tan, Yu Zong Chen, Yu Yang Jiang
Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, P. R. China
Chu Qin, Cun Long Zhang, Chun Yan Tan, Yu Zong Chen, Yu Yang Jiang
The Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology, the Graduate School at Shenzhen, Tsinghua University, Shenzhen, P. R. China
Chu Qin, Kai Leng Tan, Yu Zong Chen
Bioinformatics and Drug Design Group, Department of Pharmacy, and Center for Computational Science and Engineering, National University of Singapore, Singapore,Singapore
Chu Qin
NUS Graduate School for Integrative Sciences and Engineering, Singapore, Singapore

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CQ YYJ YZC. Performed the experiments: CQ KLT CLZ CYT YYJ YZC. Analyzed the data: CQ KLT CLZ CYT YYJ YZC. Contributed reagents/materials/analysis tools: CQ KLT CLZ. Wrote the paper: CQ YZC.