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Research Article

Angiotensin II Reduces Cardiac AdipoR1 Expression through AT1 Receptor/ROS/ERK1/2/c-Myc Pathway

  • Li Li equal contributor,

    equal contributor Contributed equally to this work with: Li Li, Zhi-Guo Zhang

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

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  • Zhi-Guo Zhang equal contributor,

    equal contributor Contributed equally to this work with: Li Li, Zhi-Guo Zhang

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

    X
  • Hong Lei,

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

    X
  • Cheng Wang,

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

    X
  • Li-Peng Wu,

    Affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China

    X
  • Jin-Yu Wang,

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

    X
  • Feng-Ying Fu,

    Affiliation: Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China

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  • Wei-Guo Zhu,

    Affiliation: Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China

    X
  • Li-Ling Wu mail

    pathophy@bjmu.edu.cn

    Affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China

    X
  • Published: January 22, 2013
  • DOI: 10.1371/journal.pone.0049915

About the Authors

Li Li, Zhi-Guo Zhang, Hong Lei, Cheng Wang, Jin-Yu Wang, Li-Ling Wu
Department of Physiology and Pathophysiology, Peking University Health Science Center, and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China
Li-Peng Wu, Wei-Guo Zhu
Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
Feng-Ying Fu
Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Ministry of Health, Beijing, China

Corresponding Author

Email: pathophy@bjmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LLW LL ZGZ. Performed the experiments: LL ZGZ HL CW FYF JYW. Analyzed the data: LL ZGZ. Contributed reagents/materials/analysis tools: LPW WGZ. Wrote the paper: LL LLW ZGZ.