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Research Article

Primary Human Ovarian Epithelial Cancer Cells Broadly Express HER2 at Immunologically-Detectable Levels

  • Evripidis Lanitis,

    Affiliations: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece

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  • Denarda Dangaj,

    Affiliations: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece

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  • Ian S. Hagemann,

    Affiliation: Abramson Cancer Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • De-Gang Song,

    Affiliation: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Andrew Best,

    Affiliation: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Raphael Sandaltzopoulos,

    Affiliation: Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece

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  • George Coukos,

    Affiliation: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Daniel J. Powell Jr mail

    poda@mail.med.upenn.edu

    Affiliations: Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Abramson Cancer Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: November 26, 2012
  • DOI: 10.1371/journal.pone.0049829

About the Authors

Evripidis Lanitis, Denarda Dangaj, De-Gang Song, Andrew Best, George Coukos, Daniel J. Powell Jr
Ovarian Cancer Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Evripidis Lanitis, Denarda Dangaj, Raphael Sandaltzopoulos
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece
Ian S. Hagemann, Daniel J. Powell Jr
Abramson Cancer Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: poda@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EL GC DP. Performed the experiments: EL DD ISH. Analyzed the data: EL DD ISH. Contributed reagents/materials/analysis tools: DS AB. Wrote the paper: EL DD RS DP.