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Research Article

Potential Downstream Target Genes of Aberrant ETS Transcription Factors Are Differentially Affected in Ewing’s Sarcoma and Prostate Carcinoma

  • Maria J. Camões equal contributor,

    equal contributor Contributed equally to this work with: Maria J. Camões, Paula Paulo

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal

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  • Paula Paulo equal contributor,

    equal contributor Contributed equally to this work with: Maria J. Camões, Paula Paulo

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal

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  • Franclim R. Ribeiro,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal

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  • João D. Barros-Silva,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal

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  • Mafalda Almeida,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Epigenetics Group, Research Centre of The Portuguese Oncology Institute, Porto, Portugal

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  • Vera L. Costa,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Epigenetics Group, Research Centre of The Portuguese Oncology Institute, Porto, Portugal

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  • Nuno Cerveira,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal

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  • Rolf I. Skotheim,

    Affiliations: Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway

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  • Ragnhild A. Lothe,

    Affiliations: Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway

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  • Rui Henrique,

    Affiliations: Cancer Epigenetics Group, Research Centre of The Portuguese Oncology Institute, Porto, Portugal, Department of Pathology, Portuguese Oncology Institute-Porto, Porto, Portugal, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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  • Carmen Jerónimo,

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Epigenetics Group, Research Centre of The Portuguese Oncology Institute, Porto, Portugal, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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  • Manuel R. Teixeira mail

    manuel.teixeira@ipoporto.min-saude.pt

    Affiliations: Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal, Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal, Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

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  • Published: November 19, 2012
  • DOI: 10.1371/journal.pone.0049819

About the Authors

Maria J. Camões, Paula Paulo, Franclim R. Ribeiro, João D. Barros-Silva, Mafalda Almeida, Vera L. Costa, Nuno Cerveira, Carmen Jerónimo, Manuel R. Teixeira
Department of Genetics, Portuguese Oncology Institute-Porto, Porto, Portugal
Maria J. Camões, Paula Paulo, Franclim R. Ribeiro, João D. Barros-Silva, Nuno Cerveira, Manuel R. Teixeira
Cancer Genetics Group, Research Centre of the Portuguese Oncology Institute-Porto, Porto, Portugal
Mafalda Almeida, Vera L. Costa, Rui Henrique, Carmen Jerónimo
Cancer Epigenetics Group, Research Centre of The Portuguese Oncology Institute, Porto, Portugal
Rolf I. Skotheim, Ragnhild A. Lothe
Department of Cancer Prevention, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
Rolf I. Skotheim, Ragnhild A. Lothe, Manuel R. Teixeira
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway
Rui Henrique
Department of Pathology, Portuguese Oncology Institute-Porto, Porto, Portugal
Rui Henrique, Carmen Jerónimo, Manuel R. Teixeira
Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal

Corresponding Author

Email: manuel.teixeira@ipoporto.min-saude.pt

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MRT. Performed the experiments: MJC PP JDBS MA VLC. Analyzed the data: MJC PP FRR. Contributed reagents/materials/analysis tools: NC RIS RAL RH CJ. Wrote the paper: MRT PP.