Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1

Jiping Zhou; Denise G. Joplin; Janet V. Cross; Dennis J. Templeton

doi:10.1371/journal.pone.0049744

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Open Access

Peer-reviewed

Research Article

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1

Jiping Zhou,

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Denise G. Joplin,

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Janet V. Cross,

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Dennis J. Templeton

* E-mail: dtempleton@virginia.edu.

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯

Sulforaphane Inhibits Prostaglandin E2 Synthesis by Suppressing Microsomal Prostaglandin E Synthase 1

Jiping Zhou,
Denise G. Joplin,
Janet V. Cross,
Dennis J. Templeton

Published: November 16, 2012
https://doi.org/10.1371/journal.pone.0049744

About the Authors

Jiping Zhou

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

Denise G. Joplin

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

Janet V. Cross

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

Dennis J. Templeton

* E-mail: dtempleton@virginia.edu.

Affiliation Department of Pathology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

Competing Interests

DJT is an academic editor of PLOS One.

Author Contributions

Conceived and designed the experiments: JZ JVC DJT. Performed the experiments: JZ DGJ JVC. Analyzed the data: JZ DGJ JVC DJT. Contributed reagents/materials/analysis tools: JZ DGJ JVC DJT. Wrote the paper: JZ JVC DJT.

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Cancers and neoplasms
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Prostaglandin
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Lung and intrathoracic tumors
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Inflammation
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COX-2 inhibitors
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Messenger RNA
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Transfection
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Renal cancer
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