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Research Article

Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

  • Hong Zhao equal contributor,

    equal contributor Contributed equally to this work with: Hong Zhao, Qinshan Li

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Qinshan Li equal contributor,

    equal contributor Contributed equally to this work with: Hong Zhao, Qinshan Li

    Affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jian Wang,

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Xianwei Su,

    Affiliation: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

    X
  • Ka Man Ng,

    Affiliation: Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong

    X
  • Tian Qiu,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Ling Shan,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Yun Ling,

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Linfang Wang,

    Affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jianqiang Cai mail,

    jmying@hotmail.com (JY); caijianqiang188@sina.com (JC)

    Affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Jianming Ying mail

    jmying@hotmail.com (JY); caijianqiang188@sina.com (JC)

    Affiliation: Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

    X
  • Published: November 13, 2012
  • DOI: 10.1371/journal.pone.0049683

About the Authors

Hong Zhao, Jian Wang, Jianqiang Cai
Department of Abdominal Surgical Oncology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
Qinshan Li, Linfang Wang
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China
Xianwei Su, Ka Man Ng
Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Oncology in South China, Sir YK Pao Center for Cancer and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong
Tian Qiu, Ling Shan, Yun Ling, Jianming Ying
Department of Pathology, Cancer Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HZ JC JY. Performed the experiments: HZ QL JW XS KMN TQ. Analyzed the data: HZ JW JC JY. Contributed reagents/materials/analysis tools: LW LS YL. Wrote the paper: JW JY.