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Research Article

Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications

  • Anne Chastre,

    Affiliation: Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada

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  • Mireille Bélanger,

    Affiliation: Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada

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  • Elizabeth Beauchesne,

    Affiliation: Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada

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  • Bich N. Nguyen,

    Affiliation: Département de pathologie, Hôpital Saint-Luc, CHUM, Montreal, Canada

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  • Paul Desjardins,

    Affiliation: Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada

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  • Roger F. Butterworth mail

    roger.butterworth@umontreal.ca

    Affiliation: Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0049670

About the Authors

Anne Chastre, Mireille Bélanger, Elizabeth Beauchesne, Paul Desjardins, Roger F. Butterworth
Neuroscience Research Unit, Hôpital Saint-Luc, CRCHUM, Montreal, Canada
Bich N. Nguyen
Département de pathologie, Hôpital Saint-Luc, CHUM, Montreal, Canada

Corresponding Author

Email: roger.butterworth@umontreal.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AC MB EB PD RFB. Performed the experiments: AC MB EB. Analyzed the data: AC MB EB BNN. Wrote the paper: AC MB PD RFB.