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Research Article

Bidirectional Scaling of Astrocytic Metabotropic Glutamate Receptor Signaling following Long-Term Changes in Neuronal Firing Rates

  • Alison X. Xie,

    Affiliation: Graduate Program in Neuroscience, University of California Riverside, Riverside, California, United States of America

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  • Min-Yu Sun,

    Affiliation: Graduate Program in Cellular, Molecular, and Developmental Biology, University of California Riverside, Riverside, California, United States of America

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  • Thomas Murphy,

    Affiliation: Graduate Program in Neuroscience, University of California Riverside, Riverside, California, United States of America

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  • Kelli Lauderdale,

    Affiliation: Graduate Program in Neuroscience, University of California Riverside, Riverside, California, United States of America

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  • Elizabeth Tiglao,

    Affiliation: Undergraduate Neuroscience Major, University of California Riverside, Riverside, California, United States of America

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  • Todd A. Fiacco mail

    todd.fiacco@ucr.edu

    Affiliation: Department of Cell Biology and Neuroscience and Center for Glial-Neuronal Interactions, University of California Riverside, Riverside, California, United States of America

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0049637

About the Authors

Alison X. Xie, Thomas Murphy, Kelli Lauderdale
Graduate Program in Neuroscience, University of California Riverside, Riverside, California, United States of America
Min-Yu Sun
Graduate Program in Cellular, Molecular, and Developmental Biology, University of California Riverside, Riverside, California, United States of America
Elizabeth Tiglao
Undergraduate Neuroscience Major, University of California Riverside, Riverside, California, United States of America
Todd A. Fiacco
Department of Cell Biology and Neuroscience and Center for Glial-Neuronal Interactions, University of California Riverside, Riverside, California, United States of America

Corresponding Author

Email: todd.fiacco@ucr.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TAF AXX. Performed the experiments: AXX MYS. Analyzed the data: AXX TAF ET. Wrote the paper: TAF AXX TM KL.