About the Authors

Takehiro Kiko

Affiliation Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Kiyotaka Nakagawa

Affiliation Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Akira Satoh

Affiliation Life Science Institute, Yamaha Motor Company, Ltd., Shizuoka, Japan

Tsuyoshi Tsuduki

Affiliation Laboratory of Food and Biomolecular Science, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Katsutoshi Furukawa

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

Hiroyuki Arai

Affiliation Department of Geriatrics and Gerontology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan

Teruo Miyazawa

miyazawa@biochem.tohoku.ac.jp

Affiliation Food and Biodynamic Chemistry Laboratory, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Competing Interests

One of the authors (AS) is employed by a commercial company (Life Science Institute, Yamaha Motor Co., Ltd.). This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TK KN AS TT KF HA TM. Performed the experiments: TK. Analyzed the data: TK KN. Contributed reagents/materials/analysis tools: TK KN AS. Wrote the paper: TK KN TM.