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Research Article

Use of Four Next-Generation Sequencing Platforms to Determine HIV-1 Coreceptor Tropism

  • John Archer equal contributor,

    equal contributor Contributed equally to this work with: John Archer, Jan Weber

    Affiliation: Computational and Evolutionary Biology, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

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  • Jan Weber equal contributor,

    equal contributor Contributed equally to this work with: John Archer, Jan Weber

    Affiliation: Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

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  • Kenneth Henry,

    Affiliation: Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Dane Winner,

    Affiliation: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Richard Gibson,

    Affiliation: Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Lawrence Lee,

    Affiliation: Pacific Biosciences, Menlo Park, California, United States of America

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  • Ellen Paxinos,

    Affiliation: Pacific Biosciences, Menlo Park, California, United States of America

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  • Eric J. Arts,

    Affiliation: Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • David L. Robertson,

    Affiliation: Computational and Evolutionary Biology, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

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  • Larry Mimms,

    Affiliation: Quidel Corporation, San Diego, California, United States of America

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  • Miguel E. Quiñones-Mateu mail

    meq@case.edu

    Affiliations: Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America, University Hospital Translational Laboratory, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049602

About the Authors

John Archer, David L. Robertson
Computational and Evolutionary Biology, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
Jan Weber
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic
Kenneth Henry, Richard Gibson, Eric J. Arts
Division of Infectious Diseases, Case Western Reserve University, Cleveland, Ohio, United States of America
Dane Winner, Miguel E. Quiñones-Mateu
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
Lawrence Lee, Ellen Paxinos
Pacific Biosciences, Menlo Park, California, United States of America
Larry Mimms
Quidel Corporation, San Diego, California, United States of America
Miguel E. Quiñones-Mateu
University Hospital Translational Laboratory, University Hospitals Case Medical Center, Cleveland, Ohio, United States of America

Corresponding Author

Email: meq@case.edu

Competing Interests

JA, JW, KH, DW, RG, EJA, DLR, and MEQ-M report no conflict of interest. LL and EP are employed by Pacific Biosciences. LM is employed by Quidel Corporation. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MEQ-M LM. Performed the experiments: JW KH DW RG LL. Analyzed the data: JA DLR MEQ-M. Wrote the paper: MEQ-M. Provided access to material, technology and critical advice: EP EJA LM.