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Research Article

Toward the Beginning of Time: Circadian Rhythms in Metabolism Precede Rhythms in Clock Gene Expression in Mouse Embryonic Stem Cells

  • Jiffin K. Paulose,

    Affiliation: Department of Biology, Center for Research on Biological Clocks, Texas A&M University, College Station, Texas, United States of America

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  • Edmund B. Rucker III,

    Affiliation: Department of Biology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Vincent M. Cassone mail

    Vincent.Cassone@uky.edu

    Affiliation: Department of Biology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049555

About the Authors

Jiffin K. Paulose
Department of Biology, Center for Research on Biological Clocks, Texas A&M University, College Station, Texas, United States of America
Edmund B. Rucker III, Vincent M. Cassone
Department of Biology, University of Kentucky, Lexington, Kentucky, United States of America

Corresponding Author

Email: Vincent.Cassone@uky.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: VMC JKP. Performed the experiments: JKP EBR. Analyzed the data: VMC JKP. Contributed reagents/materials/analysis tools: EBR VMC. Wrote the paper: JKP VMC.