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Research Article

A Low Dose of Fermented Soy Germ Alleviates Gut Barrier Injury, Hyperalgesia and Faecal Protease Activity in a Rat Model of Inflammatory Bowel Disease

  • Lara Moussa,

    Affiliations: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France, GENIBIO, Lorp-Sentaraille, France

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  • Valérie Bézirard,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Christel Salvador-Cartier,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Valérie Bacquié,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Corinne Lencina,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Mathilde Lévêque,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Viorica Braniste,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Sandrine Ménard,

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Vassilia Théodorou equal contributor,

    equal contributor Contributed equally to this work with: Vassilia Théodorou, Eric Houdeau

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Eric Houdeau equal contributor mail

    equal contributor Contributed equally to this work with: Vassilia Théodorou, Eric Houdeau

    Eric.Houdeau@toulouse.inra.fr

    Affiliation: Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049547

About the Authors

Lara Moussa, Valérie Bézirard, Christel Salvador-Cartier, Valérie Bacquié, Corinne Lencina, Mathilde Lévêque, Viorica Braniste, Sandrine Ménard, Vassilia Théodorou, Eric Houdeau
Neuro-Gastroenterology and Nutrition, Institut National de la Recherche Agronomique, UMR1331 Toxalim, INRA/INPT/UPS, Toulouse, France
Lara Moussa
GENIBIO, Lorp-Sentaraille, France

Corresponding Author

Email: Eric.Houdeau@toulouse.inra.fr

Competing Interests

The authors have the following interests. This work was partly funded by GENIBIO, the employer of Lara Moussa. The fermented soy germ ingredient (FSG) used in the study was industrially processed as ground powder under the trademark Primasoy® by GENIBIO. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: LM VT EH. Performed the experiments: LM V. Bézirard CS-C V. Bacquié CL ML V. Braniste SM. Analyzed the data: LM. Wrote the paper: LM VT EH.