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Research Article

Imaging Mass Spectrometry Visualizes Ceramides and the Pathogenesis of Dorfman-Chanarin Syndrome Due to Ceramide Metabolic Abnormality in the Skin

  • Naoko Goto-Inoue,

    Affiliation: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

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  • Takahiro Hayasaka,

    Affiliation: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

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  • Nobuhiro Zaima,

    Affiliation: Department of Applied Biological Chemistry, Kinki University, Nara, Nara, Japan

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  • Kimiko Nakajima,

    Affiliation: Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Nankoku, Japan

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  • Walter M. Holleran,

    Affiliation: Department of Dermatology, School of Medicine, University of California San Francisco, Department of Veterans Affairs Medical Center, and Northern California Institute for Research and Education, San Francisco, California, United States of America

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  • Shigetoshi Sano,

    Affiliation: Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Nankoku, Japan

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  • Yoshikazu Uchida equal contributor mail,

    equal contributor Contributed equally to this work with: Yoshikazu Uchida, Mitsutoshi Setou

    uchiday@derm.ucsf.edu (YU); setou@hama-med.ac.jp (MS)

    Affiliation: Department of Dermatology, School of Medicine, University of California San Francisco, Department of Veterans Affairs Medical Center, and Northern California Institute for Research and Education, San Francisco, California, United States of America

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  • Mitsutoshi Setou equal contributor mail

    equal contributor Contributed equally to this work with: Yoshikazu Uchida, Mitsutoshi Setou

    uchiday@derm.ucsf.edu (YU); setou@hama-med.ac.jp (MS)

    Affiliation: Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0049519

About the Authors

Naoko Goto-Inoue, Takahiro Hayasaka, Mitsutoshi Setou
Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, Japan
Nobuhiro Zaima
Department of Applied Biological Chemistry, Kinki University, Nara, Nara, Japan
Kimiko Nakajima, Shigetoshi Sano
Department of Dermatology, Kochi Medical School, Kochi University, Kohasu, Okocho, Nankoku, Nankoku, Japan
Walter M. Holleran, Yoshikazu Uchida
Department of Dermatology, School of Medicine, University of California San Francisco, Department of Veterans Affairs Medical Center, and Northern California Institute for Research and Education, San Francisco, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

  • Conceived and designed the experiments: NG-I MS YU. Performed the experiments: NG-I. Analyzed the data: NG-I TH. Contributed reagents/materials/analysis tools: NZ KN WM-H SS. Wrote the paper: NG-I MS YU.
  • . Analyzed the data: NG-I TH. Contributed reagents/materials/analysis tools: NZ KN WM-H SS. Wrote the paper: NG-I MS YU.