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Research Article

Development and Characterization of Recombinant Ovine Coagulation Factor VIII

  • Philip M. Zakas,

    Affiliation: Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia, United States of America

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  • Bagirath Gangadharan,

    Affiliation: Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Graca Almeida-Porada,

    Affiliation: Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, United States of America

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  • Christopher D. Porada,

    Affiliation: Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, United States of America

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  • H. Trent Spencer,

    Affiliation: Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Christopher B. Doering mail

    cdoerin@emory.edu

    Affiliation: Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America

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  • Published: November 09, 2012
  • DOI: 10.1371/journal.pone.0049481

About the Authors

Philip M. Zakas
Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia, United States of America
Bagirath Gangadharan, H. Trent Spencer, Christopher B. Doering
Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America
Graca Almeida-Porada, Christopher D. Porada
Wake Forest Institute for Regenerative Medicine, Winston-Salem, North Carolina, United States of America

Corresponding Author

Email: cdoerin@emory.edu

Competing Interests

Christopher Doering is an Academic Editor for PLOS ONE. However, Dr. Doering has not had any interactions with another editor concerning this manuscript. Furthermore, this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CBD PZ HTS GA CP. Performed the experiments: PZ BG. Analyzed the data: CBD PZ HTS. Contributed reagents/materials/analysis tools: GA CP. Wrote the paper: PZ CBD.