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Research Article

Somatic Mutations of PIK3R1 Promote Gliomagenesis

  • Steven N. Quayle,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Jennifer Y. Lee,

    Affiliations: Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lydia W T. Cheung,

    Affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Li Ding,

    Affiliations: The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

    X
  • Ruprecht Wiedemeyer,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Robert W. Dewan,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Emmet Huang-Hobbs,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Li Zhuang,

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Richard K. Wilson,

    Affiliations: The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

    X
  • Keith L. Ligon,

    Affiliations: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    X
  • Gordon B. Mills,

    Affiliation: Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

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  • Lewis C. Cantley,

    Affiliations: Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lynda Chin mail

    lchin@mdanderson.org

    Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

    Current address: Department of Genomic Medicine and Institute for Applied Cancer Science, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049466

About the Authors

Steven N. Quayle, Ruprecht Wiedemeyer, Robert W. Dewan, Emmet Huang-Hobbs, Li Zhuang, Keith L. Ligon, Lynda Chin
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Keith L. Ligon
Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Jennifer Y. Lee, Lewis C. Cantley
Division of Signal Transduction, Cancer Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
Jennifer Y. Lee, Lewis C. Cantley
Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America
Lydia W T. Cheung, Gordon B. Mills
Department of Systems Biology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States of America
Li Ding, Richard K. Wilson
The Genome Institute, Washington University School of Medicine, St Louis, Missouri, United States of America
Li Ding, Richard K. Wilson
Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America

Corresponding Author

Email: lchin@mdanderson.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SNQ JYL LWTC LD RKW GBM LCC LC. Performed the experiments: SNQ JYL LWTC LD RW RWD EH LZ. Analyzed the data: SNQ JYL LWTC LD RKW KLL GBM LCC LC. Wrote the paper: SNQ LC.