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Research Article

Remarkable Diversity in the Enzymes Catalyzing the Last Step in Synthesis of the Pimelate Moiety of Biotin

  • Madelyn M. Shapiro,

    Affiliation: Department of Microbiology, University of Illinois, Urbana, Illinois, United States of America

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  • Vandana Chakravartty,

    Affiliation: Department of Microbiology, University of Illinois, Urbana, Illinois, United States of America

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  • John E. Cronan mail

    j-cronan@life.uiuc.edu

    Affiliations: Department of Microbiology, University of Illinois, Urbana, Illinois, United States of America, Department of Biochemistry, University of Illinois, Urbana, Illinois, United States of America

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  • Published: November 09, 2012
  • DOI: 10.1371/journal.pone.0049440

About the Authors

Madelyn M. Shapiro, Vandana Chakravartty, John E. Cronan
Department of Microbiology, University of Illinois, Urbana, Illinois, United States of America
John E. Cronan
Department of Biochemistry, University of Illinois, Urbana, Illinois, United States of America

Corresponding Author

Email: j-cronan@life.uiuc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MMS JEC. Performed the experiments: MMS VC. Analyzed the data: MMS JEC VC. Contributed reagents/materials/analysis tools: MMS. Wrote the paper: MMS JEC.