About the Authors

Lukasz Japtok

Affiliation Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany

Katrin Schaper

Affiliation Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany

Wolfgang Bäumer

Affiliation Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine Hannover, Hannover, Germany

Heinfried H. Radeke

Affiliation Pharmazentrum Frankfurt, Clinic of the Johann Wolfgang Goethe-University, Frankfurt/Main, Germany

Se Kyoo Jeong

Affiliation Neopharm Co., Ltd., Daejeon, South-Korea

Burkhard Kleuser

kleuser@uni-potsdam.de

Affiliation Faculty of Mathematics and Natural Science, Institute of Nutritional Science, Department of Toxicology, University of Potsdam, Potsdam, Germany

Competing Interests

SKJ is employed by Neopharm Co. Ltd. Neopharm provided the Sphk-activator K6PC-5 for this study. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: LJ WB BK. Performed the experiments: LJ KS WB HHR BK. Analyzed the data: LJ WB HHR SKJ BK. Contributed reagents/materials/analysis tools: WB HHR SKJ BK. Wrote the paper: LJ KS WB BK.