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Research Article

The Plant-Derived Glucocorticoid Receptor Agonist Endiandrin A Acts as Co-Stimulator of Colonic Epithelial Sodium Channels (ENaC) via SGK-1 and MAPKs

  • Dana Kuntzsch,

    Affiliation: Department of Gastroenterology, Division of Nutritional Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Theresa Bergann,

    Affiliation: Department of Gastroenterology, Division of Nutritional Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany

    Current address: Institute of Biochemistry, Charité, Campus Virchow Klinikum, Berlin, Germany

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  • Petra Dames,

    Affiliation: Department of Gastroenterology, Division of Nutritional Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Anja Fromm,

    Affiliation: Institute of Clinical Physiology, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Michael Fromm,

    Affiliation: Institute of Clinical Physiology, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Rohan A. Davis,

    Affiliation: Eskitis Institute, Griffith University, Brisbane, Queensland, Australia

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  • Matthias F. Melzig,

    Affiliation: Institute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, Berlin, Germany

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  • Joerg D. Schulzke mail

    joerg.schulzke@charite.de

    Affiliation: Department of Gastroenterology, Division of Nutritional Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Published: November 13, 2012
  • DOI: 10.1371/journal.pone.0049426

About the Authors

Dana Kuntzsch, Theresa Bergann, Petra Dames, Joerg D. Schulzke
Department of Gastroenterology, Division of Nutritional Medicine, Charité, Campus Benjamin Franklin, Berlin, Germany
Anja Fromm, Michael Fromm
Institute of Clinical Physiology, Charité, Campus Benjamin Franklin, Berlin, Germany
Rohan A. Davis
Eskitis Institute, Griffith University, Brisbane, Queensland, Australia
Matthias F. Melzig
Institute of Pharmacy, Pharmaceutical Biology, Freie Universität Berlin, Berlin, Germany

Corresponding Author

Email: joerg.schulzke@charite.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DK TB JDS. Performed the experiments: DK. Analyzed the data: DK TB AF JDS. Contributed reagents/materials/analysis tools: DK TB AF MF RAD JDS. Wrote the paper: DK TB JDS. Critical revision of the paper for important intellectual content: PD AF MF RAD MFM.