About the Authors

Pamela Aubert

Affiliation Translational Autoinflammatory Disease Section NIAMS/NIH, Bethesda, Maryland, United States of America

Mayte Suárez-Fariñas

Affiliations Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America, Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America

Hiroshi Mitsui

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Leanne M. Johnson-Huang

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Jamie Lynn Harden

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Katherine C. Pierson

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Joseph G. Dolan

Affiliation Translational Autoinflammatory Disease Section NIAMS/NIH, Bethesda, Maryland, United States of America

Inna Novitskaya

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Israel Coats

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Jacob Estes

Affiliation SAIC, Frederick, Maryland, United States of America

Edward W. Cowen

Affiliation Dermatology, NCI/NIH, Bethesda, Maryland, United States of America

Nicole Plass

Affiliation Translational Autoinflammatory Disease Section NIAMS/NIH, Bethesda, Maryland, United States of America

Chyi-Chia Richard Lee

Affiliation Laboratory of Pathology, NCI/NIH, Bethesda, Maryland, United States of America

Hong-Wei Sun

Affiliation Biodata Mining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, United States of America

Michelle A. Lowes

Contributed equally to this work with: Michelle A. Lowes, Raphaela Goldbach-Mansky

Affiliation Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America

Raphaela Goldbach-Mansky

Contributed equally to this work with: Michelle A. Lowes, Raphaela Goldbach-Mansky

goldbacr@arb.niams.nih.gov

Affiliation Translational Autoinflammatory Disease Section NIAMS/NIH, Bethesda, Maryland, United States of America

Competing Interests

Dr RG-M has received grant support from Regeneron and Novartis for clinical studies in patients with CAPS. This research was completed while PA was a fellow in the the Clinical Research Training Program, a public-private partnership supported jointly by the National Institutes of Health and Pfizer Inc (via a grant to the Foundation for NIH from Pfizer Inc). JE is employed by Frederick SAI. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PA HM LMJ-H KCP JE MAL RG-M. Performed the experiments: PA HM LMJ-H KCP JLH. Analyzed the data: PA MSF HM H-WS RG-M JLH EWC NP. Contributed reagents/materials/analysis tools: MS HM LMJ-H KCP JD IN IC JE CRL MAL RG-M JLH. Wrote the paper: PA ML RG-M.