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Research Article

Negative Regulation of Hepatitis C Virus Specific Immunity Is Highly Heterogeneous and Modulated by Pegylated Interferon-Alpha/Ribavirin Therapy

  • Mark A. A. Claassen,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Robert J. de Knegt,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Duygu Turgut,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Zwier M. A. Groothuismink,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Harry L. A. Janssen,

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • André Boonstra mail

    p.a.boonstra@erasmusmc.nl

    Affiliation: Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0049389

About the Authors

Mark A. A. Claassen, Robert J. de Knegt, Duygu Turgut, Zwier M. A. Groothuismink, Harry L. A. Janssen, André Boonstra
Department of Gastroenterology and Hepatology, Erasmus MC – University Medical Center Rotterdam, Rotterdam, The Netherlands

Corresponding Author

Email: p.a.boonstra@erasmusmc.nl

Competing Interests

HLAJ received grants from and is a consultant for: Bristol Myers Squibb, Gilead Sciences, Novartis, Roche, Merck. RJdeK received grants from or is a consultant for Schering–Plough, Roche and Medtronic. This does not alter the authors’ adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MAAC RJdeK HLAJ AB. Performed the experiments: MAAC DT ZMAG. Analyzed the data: MAAC AB. Wrote the paper: MAAC RJdeK HLAJ AB.