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Research Article

Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU

  • Andrei S. Halavaty,

    Affiliations: Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America

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  • Dominika Borek,

    Affiliations: Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Gregory H. Tyson,

    Affiliation: Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Jeff L. Veesenmeyer,

    Affiliation: Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

    Current address: Department of Bacteriology, University of Wisconsin at Madison, Madison, Wisconsin, United States of America

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  • Ludmilla Shuvalova,

    Affiliations: Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America

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  • George Minasov,

    Affiliations: Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America

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  • Zbyszek Otwinowski,

    Affiliations: Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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  • Alan R. Hauser equal contributor,

    equal contributor Contributed equally to this work with: Alan R. Hauser, Wayne F. Anderson

    Affiliation: Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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  • Wayne F. Anderson equal contributor mail

    equal contributor Contributed equally to this work with: Alan R. Hauser, Wayne F. Anderson

    wf-anderson@northwestern.edu.

    Affiliations: Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049388

About the Authors

Andrei S. Halavaty, Ludmilla Shuvalova, George Minasov, Wayne F. Anderson
Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
Andrei S. Halavaty, Dominika Borek, Ludmilla Shuvalova, George Minasov, Zbyszek Otwinowski, Wayne F. Anderson
Center for Structural Genomics of Infectious Diseases (CSGID), Chicago, Illinois, United States of America
Dominika Borek, Zbyszek Otwinowski
University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
Gregory H. Tyson, Jeff L. Veesenmeyer, Alan R. Hauser
Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Corresponding Author

Email: wf-anderson@northwestern.edu.

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ASH DB GHT ZO GM LS. Performed the experiments: ASH DB GHT LS GM. Analyzed the data: ASH GHT DB JLV ZO. Contributed reagents/materials/analysis tools: JLV ARH WFA. Wrote the paper: ASH ARH WFA.