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Research Article

Paradoxical Relationship between Mn Superoxide Dismutase Deficiency and Radiation-Induced Cognitive Defects

  • Rikki Corniola,

    Affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America

    Current address: Department of Medical Education, California Northstate University College of Medicine, Elk Grove, California, United States of America

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  • Yani Zou,

    Affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America

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  • David Leu,

    Affiliations: Palo Alto Institute for Research and Education, Palo Alto, California, United States of America, Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, California, United States of America

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  • John R. Fike,

    Affiliation: Departments of Neurosurgery and Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America

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  • Ting-Ting Huang mail

    tthuang@stanford.edu

    Affiliations: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America, Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, California, United States of America

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0049367

About the Authors

Rikki Corniola, Yani Zou, Ting-Ting Huang
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, United States of America
David Leu
Palo Alto Institute for Research and Education, Palo Alto, California, United States of America
John R. Fike
Departments of Neurosurgery and Radiation Oncology, University of California San Francisco, San Francisco, California, United States of America
David Leu, Ting-Ting Huang
Geriatric Research, Education, and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, California, United States of America

Corresponding Author

Email: tthuang@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TTH JRF RC. Performed the experiments: RC YZ DL. Analyzed the data: RC TTH DL YZ. Wrote the paper: RC TTH JRF.