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Research Article

Lysosomotropic Properties of Weakly Basic Anticancer Agents Promote Cancer Cell Selectivity In Vitro

  • Rosemary A. Ndolo,

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • Yepeng Luan,

    Affiliation: Institute of Medicinal Chemistry, Shandong University, Jinan, Shandong, China

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  • Shaofeng Duan,

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • M. Laird Forrest,

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • Jeffrey P. Krise mail

    krise@ku.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0049366

About the Authors

Rosemary A. Ndolo, Shaofeng Duan, M. Laird Forrest, Jeffrey P. Krise
Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas, United States of America
Yepeng Luan
Institute of Medicinal Chemistry, Shandong University, Jinan, Shandong, China

Corresponding Author

Email: krise@ku.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JK RN MF. Performed the experiments: RN YL SD. Analyzed the data: JK RN MF. Contributed reagents/materials/analysis tools: JK MF. Wrote the paper: JK RN.