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Research Article

The Co-Chaperone Hch1 Regulates Hsp90 Function Differently than Its Homologue Aha1 and Confers Sensitivity to Yeast to the Hsp90 Inhibitor NVP-AUY922

  • Heather Armstrong,

    Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Annemarie Wolmarans,

    Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Rebecca Mercier,

    Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • BaoChan Mai,

    Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Paul LaPointe mail

    paul.lapointe@ualberta.ca

    Affiliation: Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049322

About the Authors

Heather Armstrong, Annemarie Wolmarans, Rebecca Mercier, BaoChan Mai, Paul LaPointe
Department of Cell Biology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

Corresponding Author

Email: paul.lapointe@ualberta.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HA AW RM BM PL. Performed the experiments: HA AW BM PL. Analyzed the data: HA AW BM PL. Contributed reagents/materials/analysis tools: HA AW RM BM PL. Wrote the paper: PL.