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Research Article

Role of PheE15 Gate in Ligand Entry and Nitric Oxide Detoxification Function of Mycobacterium tuberculosis Truncated Hemoglobin N

  • Ana Oliveira equal contributor,

    equal contributor Contributed equally to this work with: Ana Oliveira, Sandeep Singh

    Affiliation: Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain

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  • Sandeep Singh equal contributor,

    equal contributor Contributed equally to this work with: Ana Oliveira, Sandeep Singh

    Affiliation: CSIR-Institute of Microbial Technology, Chandigarh, India

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  • Axel Bidon-Chanal,

    Affiliation: Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain

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  • Flavio Forti,

    Affiliation: Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain

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  • Marcelo A. Martí,

    Affiliation: Departamento de Química Inorgánica, Analítica y Química Física/Instituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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  • Leonardo Boechi,

    Affiliation: Departamento de Química Inorgánica, Analítica y Química Física/Instituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

    X
  • Dario A. Estrin,

    Affiliation: Departamento de Química Inorgánica, Analítica y Química Física/Instituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

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  • Kanak L. Dikshit mail,

    kanak@imtech.res.in (KLD); fjluque@ub.edu (FJL)

    Affiliation: CSIR-Institute of Microbial Technology, Chandigarh, India

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  • F. Javier Luque mail

    kanak@imtech.res.in (KLD); fjluque@ub.edu (FJL)

    Affiliation: Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0049291

About the Authors

Ana Oliveira, Axel Bidon-Chanal, Flavio Forti, F. Javier Luque
Department of Physical Chemistry and Institute of Biomedicine (IBUB), Faculty of Pharmacy, University of Barcelona - Recinte Torribera, Santa Coloma de Gramenet, Spain
Sandeep Singh, Kanak L. Dikshit
CSIR-Institute of Microbial Technology, Chandigarh, India
Marcelo A. Martí, Leonardo Boechi, Dario A. Estrin
Departamento de Química Inorgánica, Analítica y Química Física/Instituto de Química Física de los Materiales, Medio Ambiente y Energía (INQUIMAE), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DAE KLD FJL. Performed the experiments: AO SS ABC FF LB MAM. Analyzed the data: ABC MAM DAE KLD FJL. Wrote the paper: DAE KLD FJL.