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Research Article

Metformin Inhibits Glutaminase Activity and Protects against Hepatic Encephalopathy

  • Javier Ampuero,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Isidora Ranchal,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • David Nuñez,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • María del Mar Díaz-Herrero,

    Affiliation: Department of Molecular Biology, University of Sevilla, Sevilla, Spain

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  • Marta Maraver,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • José Antonio del Campo,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Ángela Rojas,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Inés Camacho,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Blanca Figueruela,

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Juan D. Bautista,

    Affiliation: Department of Molecular Biology, University of Sevilla, Sevilla, Spain

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  • Manuel Romero-Gómez mail

    mromerogomez@us.es

    Affiliation: Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0049279

About the Authors

Javier Ampuero, Isidora Ranchal, David Nuñez, Marta Maraver, José Antonio del Campo, Ángela Rojas, Inés Camacho, Blanca Figueruela, Manuel Romero-Gómez
Unit for Clinical Management of Digestive Diseases and CIBERehd, Hospital Universitario de Valme, University of Sevilla, Sevilla, Spain
María del Mar Díaz-Herrero, Juan D. Bautista
Department of Molecular Biology, University of Sevilla, Sevilla, Spain

Corresponding Author

Email: mromerogomez@us.es

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JA MRG. Performed the experiments: IR MdMDH JAdC AR IC JDB. Analyzed the data: JA MRG. Contributed reagents/materials/analysis tools: DN MM BF. Wrote the paper: JA MRG.