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Research Article

Quercetin Suppresses Drug-Resistant Spheres via the p38 MAPK–Hsp27 Apoptotic Pathway in Oral Cancer Cells

  • Su-Feng Chen,

    Affiliation: Department of Dental Hygiene, China Medical University, Taichung, Taiwan

    X
  • Shin Nieh equal contributor mail,

    equal contributor Contributed equally to this work with: Shin Nieh, Yaoh-Shiang Lin

    niehshin1014@yahoo.com.tw (SN); yaohshiang@gmail.com (Y-SL)

    Affiliation: Department of Pathology, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan

    X
  • Shu-Wen Jao,

    Affiliation: Division of Colon and Rectal Surgery, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan

    X
  • Chia-Lin Liu,

    Affiliation: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

    X
  • Chien-Hua Wu,

    Affiliation: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

    X
  • Yun-Ching Chang,

    Affiliation: Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

    X
  • Chin-Yuh Yang,

    Affiliation: Department of Dentistry, Shuang Ho Hospital & Taipei Medical University, Taipei, Taiwan

    X
  • Yaoh-Shiang Lin equal contributor mail

    equal contributor Contributed equally to this work with: Shin Nieh, Yaoh-Shiang Lin

    niehshin1014@yahoo.com.tw (SN); yaohshiang@gmail.com (Y-SL)

    Affiliations: Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan, Department of Otolaryngology-Head and Neck Surgery, Chung Shan Medical University, Taichung, Taiwan

    X
  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0049275

About the Authors

Su-Feng Chen
Department of Dental Hygiene, China Medical University, Taichung, Taiwan
Shin Nieh
Department of Pathology, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan
Shu-Wen Jao
Division of Colon and Rectal Surgery, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan
Chia-Lin Liu, Chien-Hua Wu, Yun-Ching Chang
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
Chin-Yuh Yang
Department of Dentistry, Shuang Ho Hospital & Taipei Medical University, Taipei, Taiwan
Yaoh-Shiang Lin
Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital & National Defense Medical Center, Taipei, Taiwan
Yaoh-Shiang Lin
Department of Otolaryngology-Head and Neck Surgery, Chung Shan Medical University, Taichung, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SFC SN YSL. Performed the experiments: SFC SN YSL. Analyzed the data: SFC SN YSL CLL SWJ CYY. Contributed reagents/materials/analysis tools: CLL CHW YCC. Wrote the paper: SFC SN YSL.