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Research Article

Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes

  • Dermot Phelan equal contributor,

    equal contributor Contributed equally to this work with: Dermot Phelan, Chris Watson, Ken McDonald

    Affiliations: Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland, School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Chris Watson equal contributor,

    equal contributor Contributed equally to this work with: Dermot Phelan, Chris Watson, Ken McDonald

    Affiliation: School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Ramon Martos,

    Affiliations: Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland, School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Patrick Collier,
  • Anil Patle,

    Affiliation: Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland

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  • Seamas Donnelly,

    Affiliation: School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Mark Ledwidge,

    Affiliation: Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland

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  • John Baugh mail,

    John.Baugh@ucd.ie

    Affiliation: School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Ken McDonald equal contributor

    equal contributor Contributed equally to this work with: Dermot Phelan, Chris Watson, Ken McDonald

    Affiliations: Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland, School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0049259

About the Authors

Dermot Phelan, Ramon Martos, Anil Patle, Mark Ledwidge, Ken McDonald
Heart Failure Unit, St Vincent’s University Hospital, Elm Park, Dublin, Ireland
Dermot Phelan, Chris Watson, Ramon Martos, Seamas Donnelly, John Baugh, Ken McDonald
School of Medicine and Medical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

Corresponding Author

Email: John.Baugh@ucd.ie

Competing Interests

This research was in part funded by a research bursary allocated by the Irish Heart Foundation which was funded by Pfizer. Pfizer had no input into the allocation of the bursary. The research was preformed completely independently of Pfizer. Pfizer had no input into the design or execution of the study or in the data analysis or manuscript preparation. No additional external funding was received for this study. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials. There are no other relevant declarations relating to employment, consultancy, patents and products in development or marketed products.

Author Contributions

Conceived and designed the experiments: DP CW RM SD ML JB KMD. Performed the experiments: DP RM CW PC AP. Analyzed the data: DP CW PC JB ML KMD. Contributed reagents/materials/analysis tools: KMD. Wrote the paper: DP CW JB KMD.