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Research Article

Mid-Gestational Gene Expression Profile in Placenta and Link to Pregnancy Complications

  • Liis Uusküla,

    Affiliation: Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Jaana Männik,

    Affiliations: Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, United States of America

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  • Kristiina Rull,

    Affiliations: Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia, Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia

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  • Ave Minajeva,

    Affiliation: Department of Pathology, Tartu University Hospital, Tartu, Estonia

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  • Sulev Kõks,

    Affiliation: Department of Physiology, Center of Translational Medicine, University of Tartu, Tartu, Estonia

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  • Pille Vaas,

    Affiliation: Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia

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  • Pille Teesalu,

    Affiliation: Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia

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  • Jüri Reimand mail,

    maris.laan@ut.ee (ML); Juri.Reimand@utoronto.ca (JR)

    Affiliation: Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

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  • Maris Laan mail

    maris.laan@ut.ee (ML); Juri.Reimand@utoronto.ca (JR)

    Affiliation: Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0049248

About the Authors

Liis Uusküla, Jaana Männik, Kristiina Rull, Maris Laan
Human Molecular Genetics Group, Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Jaana Männik
Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee, Knoxville, Tennessee, United States of America
Kristiina Rull, Pille Vaas, Pille Teesalu
Department of Obstetrics and Gynecology, Tartu University Hospital, Tartu, Estonia
Ave Minajeva
Department of Pathology, Tartu University Hospital, Tartu, Estonia
Sulev Kõks
Department of Physiology, Center of Translational Medicine, University of Tartu, Tartu, Estonia
Jüri Reimand
Donnelly Centre, University of Toronto, Toronto, Ontario, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ML LU JR KR JM. Performed the experiments: LU KR JM AM. Analyzed the data: JR SK LU JM. Contributed reagents/materials/analysis tools: ML JR. Wrote the paper: LU ML JR JM. Large-scle bioinformatic data analysis: JR. Recruitment of the study participants and collection of clinical information: PV PT KR. Collection and management of the biological samples of the study: PV PT KR ML JM. Interpretation of the study data: ML LU JM JR KR AM. Critical reading and commenting of the manuscript: KR AM SK PV. Approval of the final manuscript: LU JM KR AM SK PV PT JR ML.