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Research Article

Engineering Tocopherol Selectivity in α-TTP: A Combined In Vitro/In Silico Study

  • Rachel E. Helbling,

    Affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

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  • Walter Aeschimann,

    Affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

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  • Fabio Simona,

    Affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

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  • Achim Stocker mail,

    achim.stocker@ibc.unibe.ch (AS); michele.cascella@iac.unibe.ch (MC)

    Affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

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  • Michele Cascella mail

    achim.stocker@ibc.unibe.ch (AS); michele.cascella@iac.unibe.ch (MC)

    Affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

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  • Published: November 13, 2012
  • DOI: 10.1371/journal.pone.0049195

About the Authors

Rachel E. Helbling, Walter Aeschimann, Fabio Simona, Achim Stocker, Michele Cascella
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS MC. Performed the experiments: REH WA. Analyzed the data: REH FS WA AS MC. Contributed reagents/materials/analysis tools: AS MC. Wrote the paper: REH WA MC. Initial system setup for simulations: FS.